Francesco Onofrio Manfredini (22 June 1684 – 6 October 1762) was an Italian Baroque composer, violinist, and church musician.

He was born at Pistoia to a trombonist. He studied violin with Giuseppe Torelli in Bologna, then a part of the Papal States, a leading figure in the development of the concerto grosso. He also took instruction in composition from Giacomo Antonio Perti, maestro di cappella of the Basilica of San Petronio from 1696 when the orchestra was temporarily disbanded.

Although he composed oratorios, only his secular works remain in the repertoire. A contemporary of Johann Sebastian Bach and Antonio Vivaldi, his extant work shows the influence of the latter.